Addison's Disease Research Today is a free monthly online journal that collates and summarizes the latest research about Addison's Disease, including details on chronic adrenal insufficiency, treatment, causes, medication.

Antiphospholipid syndrome during pegylated interferon alpha-2a therapy for chronic hepatitis C.

Balderramo DC, García O, Colmenero J, Espinosa G, Forns X, Ginès P

Liver Unit, Institut Clínic de Malalties Digestives i Metabòliques, Hospital Clínic, Villarroel 170, 08036, Barcelona, Catalonia, Spain.

A great variety of autoimmune side effects have been reported during interferon alpha therapy. The presence of anticardiolipin antibodies during interferon alpha therapy in chronic hepatitis C has also been reported. There are no reports on the occurrence of antiphospholipid syndrome in patients with chronic hepatitis C while on pegylated interferon alpha therapy. We report a case of a 46-year-old man who developed antiphospholipid syndrome 12 weeks after starting pegylated interferon alpha plus ribavirin for chronic hepatitis C. The clinical presentation of antiphospholipid syndrome was primary adrenal insufficiency secondary to bilateral adrenal haematoma and subclavian vein thrombosis. A pathogenic role of pegylated interferon alpha as a trigger factor for antiphospholipid syndrome development is suggested.

Published 4 February 2008 in Dig Liver Dis.
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